There is an urge to find new chemical entities as potent antibiotics due to the advancement in microbial resistance. DNA gyrase is an essential enzyme in bacteria, and its inhibition results in the disruption of DNA synthesis and, subsequently, cell death. With the objective, novel piperidine molecules were designed and docked against DNA gyrase enzyme using glide software. From the docking result the compound DAL IIA (1-chloro-2,6-diisopropylpiperidin-4-one) showed potent tight binding against the protein DNA gyrase (PDB: 3U2D) with a glide score of -7.58 which is equal to the binding effect of standard streptomycin -7.62 and ketaconazole -6.95.
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